Genetic variations in toll-like receptor 4 in Mexican-Mestizo patients with intra-abdominal infection and/or pneumonia

Highlights • Prevalence of 299G/399I in Mexican-Mestizos was lower than that of other populations. • The study was not able to detect associations between TLR4 SNPs and sepsis. • The study emphasizes the variable distribution of TLR4 SNPs among populations.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2013-06, Vol.153 (1), p.41-46
Hauptverfasser:	Rodriguez-Osorio, Carlos A, Lima, Guadalupe, Herrera-Caceres, Jaime O, Villegas-Torres, Beatriz E, Zuñiga, Joaquin, Ponce-de-Leon, Sergio, Llorente, Luis, Sifuentes-Osornio, Jose
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Allergy and Immunology Case-Control Studies Female Fungi - immunology Genetic Predisposition to Disease Genetic Variation Genotype Gram-Negative Bacteria - immunology Gram-Positive Bacteria - immunology Humans Intraabdominal Infections - genetics Intraabdominal Infections - immunology Male Mestizo Mexico Middle Aged Pneumonia - genetics Pneumonia - immunology Polymorphism Polymorphism, Single Nucleotide Risk Sepsis Sepsis - genetics SNP TLR4 Toll-Like Receptor 4 - genetics Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Prevalence of 299G/399I in Mexican-Mestizos was lower than that of other populations. • The study was not able to detect associations between TLR4 SNPs and sepsis. • The study emphasizes the variable distribution of TLR4 SNPs among populations.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2013.07.002