Association of forkhead box J3 (FOXJ3) polymorphisms with rheumatoid arthritis

The aim of this study was to investigate the correlation between single nucleotide polymorphisms (SNPs) of the forkhead box J3 (FOXJ3) gene and rheumatoid arthritis (RA). For the association studies, 307 patients with RA and 476 control patients without RA were recruited. Eleven SNPs (rs2282404, rs2...

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Veröffentlicht in:	Molecular medicine reports 2013-10, Vol.8 (4), p.1235-1241
Hauptverfasser:	BAN, JU YEON, PARK, HAE JEONG, KIM, SU KANG, KIM, JONG WOO, LEE, YEON-AH, CHOI, IN-AH, CHUNG, JOO-HO, HONG, SEUNG-JAE
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Autoantibodies - blood Blood Sedimentation C-Reactive Protein - metabolism Case-Control Studies Cell Cycle Proteins - genetics Citrulline Confidence intervals Data processing Deoxyribonucleic acid Disease DNA Female forkhead box J3 Forkhead protein Forkhead Transcription Factors - genetics Gene Frequency Genes Genetic Association Studies Genetic Predisposition to Disease Genomes haplotype Haplotypes Humans Linkage Disequilibrium Male Middle Aged Peptides Peptides, Cyclic - immunology polymorphism Polymorphism, Single Nucleotide Rheumatoid arthritis Sequence Analysis, DNA Single-nucleotide polymorphism Software Studies Transcription factors Values
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Zusammenfassung:	The aim of this study was to investigate the correlation between single nucleotide polymorphisms (SNPs) of the forkhead box J3 (FOXJ3) gene and rheumatoid arthritis (RA). For the association studies, 307 patients with RA and 476 control patients without RA were recruited. Eleven SNPs (rs2282404, rs2455084, rs1393009, rs7539485, rs4660616, rs510157, rs343386, rs12732892, rs343389, rs343376 and rs585320) were genotyped using direct sequencing and the resulting data were analyzed using the SNPStats, Haploview and Helixtree programs. Seven SNPs (rs2455084, rs1393009, rs7539485, rs4660616, rs510157, rs343386 and rs343389) were associated with RA in three alternative models (log-additive, dominant and recessive models; P
ISSN:	1791-2997 1791-3004
DOI:	10.3892/mmr.2013.1623