Seizure associated with induction of anesthesia with isoflurane

All previous studies have concluded that, although isoflurane may cause high-voltage synchronous spikes in dogs and cats, it does not produce electroencephalographic (EEG) or clinical seizures in humans, even when administered in high concentrations and in association with hypocapnia and photic or auditory stimulation. The authors present a patient who twice had seizures during the induction of anesthesia using isoflurane and nitrous oxide.