Cognitive impairment and vitamin B12: a review

Background: This review examines the associations between low vitamin B12 levels, neurodegenerative disease, and cognitive impairment. The potential impact of comorbidities and medications associated with vitamin B12 derangements were also investigated. In addition, we reviewed the evidence as to wh...

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Veröffentlicht in:	International psychogeriatrics 2012-04, Vol.24 (4), p.541-556
Hauptverfasser:	Moore, Eileen, Mander, Alastair, Ames, David, Carne, Ross, Sanders, Kerrie, Watters, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alzheimer Disease - drug therapy Alzheimer Disease - etiology Biological and medical sciences Cognition & reasoning Cognition Disorders - drug therapy Cognition Disorders - etiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Dementia - drug therapy Dementia - etiology Geriatric psychology Geriatrics Humans Medical sciences Neurology Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology Psychopathology. Psychiatry Vitamin B Vitamin B 12 - therapeutic use Vitamin B 12 Deficiency - complications Vitamin B 12 Deficiency - drug therapy Vitamins - therapeutic use
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Zusammenfassung:	Background: This review examines the associations between low vitamin B12 levels, neurodegenerative disease, and cognitive impairment. The potential impact of comorbidities and medications associated with vitamin B12 derangements were also investigated. In addition, we reviewed the evidence as to whether vitamin B12 therapy is efficacious for cognitive impairment and dementia. Methods: A systematic literature search identified 43 studies investigating the association of vitamin B12 and cognitive impairment or dementia. Seventeen studies reported on the efficacy of vitamin B12 therapy for these conditions. Results: Vitamin B12 levels in the subclinical low-normal range (
ISSN:	1041-6102 1741-203X
DOI:	10.1017/S1041610211002511