Genetically Determined Hemocoagulatory Abnormalities as a Cause of Ischemic Strokes in Children

We present here results from studies of the histories of thrombosis and polymorphisms of the hemocoagulation system genes in 27 children with ischemic stroke. The structures of allelic variants are compared in the Russian and non-Russian populations. All patients had more than four procoagulatory mutations. The most frequent were polymorphisms of the FGB fibrinogen gene (G-455A), the ITGA2 thrombocyte receptor gene (C807T), and the PAI-1 fibrinolysin gene (675 4G4G). The family histories of 81.5% of the children included thrombotic episodes and vascular events in relatives aged less than 50 years. Current data on the frequencies of mutations in populations of sick and healthy children are analyzed, along with their phenotypic characteristics.