Barrier elements of chromatin domains and nuclear envelope

Barrier elements of chromatin domains and nuclear envelope

The results of investigating the functions of different barrier elements, including insulators and MARs/SARs and the models of their effect, are described. The functions of neDNA (DNA from the nuclear envelopes) as a barrier element that protects the transgene from position-effect variegation and it...

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Veröffentlicht in:Russian journal of genetics 2013, Vol.49 (1), p.23-28
Hauptverfasser: Shabarina, A. N., Glazkov, M. V.
Format: Artikel
Sprache:eng
Schlagworte:
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Chromatin
Human Genetics
Microbial Genetics and Genomics
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Beschreibung
Zusammenfassung:The results of investigating the functions of different barrier elements, including insulators and MARs/SARs and the models of their effect, are described. The functions of neDNA (DNA from the nuclear envelopes) as a barrier element that protects the transgene from position-effect variegation and its interaction with insulators are discussed. The possible mechanisms of the functioning of structural and functional units of eukaryotic chromosomes of different species are suggested.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795413010122