Obesity impairs wound closure through a vasculogenic mechanism

Obesity impairs wound closure through a vasculogenic mechanism

Since obesity impairs wound healing and bone marrow (BM)‐derived vasculogenic progenitor cells (PCs) are important for tissue repair, we hypothesize that obesity‐impaired wound healing is due, in part, to impaired PC mobilization, trafficking, and function. Peripheral blood was obtained from nondiab...

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Veröffentlicht in:Wound repair and regeneration 2012-07, Vol.20 (4), p.512-522
Hauptverfasser: Wagner, I. Janelle, Szpalski, Caroline, Allen Jr, Robert J., Davidson, Edward H., Canizares, Orlando, Saadeh, Pierre B., Warren, Stephen M.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Animals
Cell Adhesion
Cell Proliferation
Disease Models, Animal
Female
Humans
Male
Mice
Mice, Obese
Middle Aged
Neovascularization, Physiologic
Obesity - complications
Obesity - pathology
Obesity - physiopathology
Stem Cells - metabolism
Stem Cells - pathology
Tissue and Organ Harvesting
Wound Healing
Wounds and Injuries - pathology
Wounds and Injuries - physiopathology
Young Adult
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Zusammenfassung:Since obesity impairs wound healing and bone marrow (BM)‐derived vasculogenic progenitor cells (PCs) are important for tissue repair, we hypothesize that obesity‐impaired wound healing is due, in part, to impaired PC mobilization, trafficking, and function. Peripheral blood was obtained from nondiabetic, obese (BMI > 30, n = 25), and nonobese (BMI 
ISSN:1067-1927
1524-475X
DOI:10.1111/j.1524-475X.2012.00803.x