Genes of detoxification are important modulators of hereditary medullary thyroid carcinoma risk

Summary Context Different inherited profiles of genes involved in cellular mechanisms of activation and detoxification of carcinogenic products can provide specific protection or determine the risk for cancer. Low‐penetrance polymorphic genes related to the biotransformation of environmental toxins have been associated with susceptibility to and the phenotype of, human tumours. Objective To investigate the role of germline inheritance of polymorphisms in CYP1A2*F, CYP1A1 m1, GSTP1, NAT2 and TP53 genes in hereditary medullary thyroid carcinoma (HMTC) patients. Design This study was developed in University of Campinas (Unicamp). Patients We studied 132 patients with HMTC, 88 first‐degree relatives of HMTC patients and 575 control individuals. Measurements All patients with MTC and their relatives were sequenced for the RET gene and five genes were genotyped using TaqMan® system. Results We observed that the inheritance of CYP1A2*F (OR = 2·10; 95% CI = 1·11–3·97; P = 0·022), GSTP1 (OR = 4·41; 95% CI = 2·47–7·88; P