Polymorphisms in schizophrenia candidate gene UFD1L may contribute to cognitive deficits

Abstract We aimed to investigate UFD1L polymorphisms in schizophrenia and in relation to cognition. A total of 299 cases and 363 controls were genotyped, and 130 patients completed nine neuropsychological tests. We found that rs5992403 AA-genotype carriers showed lower scores on the set-shifting tas...

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Veröffentlicht in:	Psychiatry research 2013-08, Vol.209 (1), p.110-113
Hauptverfasser:	Ota, Vanessa K, Berberian, Arthur A, Gadelha, Ary, Santoro, Marcos L, Ottoni, Gustavo L, Matsuzaka, Camila T, Mari, Jair J, Melaragno, Maria I, Lara, Diogo R, Smith, Marília A.C, Belangero, Sintia I, Bressan, Rodrigo A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Analysis of Variance Attention - physiology Biological and medical sciences Cognition Cognition Disorders - etiology Cognition Disorders - genetics Executive functions Female Gene Genetic Predisposition to Disease - genetics Genotype Humans Inhibition (Psychology) Male Medical sciences Neuropsychological Tests Polymorphism, Single Nucleotide - genetics Proteins - genetics Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - complications Schizophrenia - genetics Verbal Learning
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Zusammenfassung:	Abstract We aimed to investigate UFD1L polymorphisms in schizophrenia and in relation to cognition. A total of 299 cases and 363 controls were genotyped, and 130 patients completed nine neuropsychological tests. We found that rs5992403 AA-genotype carriers showed lower scores on the set-shifting task. Therefore, UFD1L may participate in the core cognitive deficits observed in schizophrenia.
ISSN:	0165-1781 1872-7123
DOI:	10.1016/j.psychres.2013.03.035