Preparation, characterization and pharmacological evaluation of tolterodine hydrogels for the treatment of overactive bladder

Effects of tolterodine hydrogels and tolterodine tablets on the cumulative urinary output in rats. In this study, transdermal gel formulations for tolterodine were developed to investigate the effects of gel matrix and chemical enhancers on drug skin permeation from tolterodine hydrogels. In vitro p...

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Veröffentlicht in:	International journal of pharmaceutics 2013-09, Vol.454 (1), p.532-538
Hauptverfasser:	Sun, Fengying, Sui, Cheng, Zhou, Yulin, Liu, Ximing, Shi, Yanan, Wu, Yi, Li, Youxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - chemistry Acrylic Resins - toxicity Administration, Cutaneous Animals Benzhydryl Compounds - administration & dosage Benzhydryl Compounds - chemistry Benzhydryl Compounds - pharmacokinetics Benzhydryl Compounds - pharmacology Benzhydryl Compounds - toxicity Biological Availability Biotransformation Chemistry, Pharmaceutical Cresols - administration & dosage Cresols - chemistry Cresols - pharmacokinetics Cresols - pharmacology Cresols - toxicity Drug Carriers Hydrogels Injections, Intravenous Male Mice Models, Biological Muscarinic Antagonists - administration & dosage Muscarinic Antagonists - chemistry Muscarinic Antagonists - pharmacokinetics Muscarinic Antagonists - pharmacology Muscarinic Antagonists - toxicity Muscle Contraction - drug effects Permeability Pharmacodynamics Pharmacokinetics Phenylpropanolamine - administration & dosage Phenylpropanolamine - chemistry Phenylpropanolamine - pharmacokinetics Phenylpropanolamine - pharmacology Phenylpropanolamine - toxicity Pyrrolidinones - administration & dosage Pyrrolidinones - chemistry Pyrrolidinones - pharmacology Rabbits Rats Skin - drug effects Skin - metabolism Skin Absorption - drug effects Skin Irritancy Tests Technology, Pharmaceutical - methods Tolterodine Tolterodine Tartrate Transdermal Urinary Bladder - drug effects Urinary Bladder, Overactive - drug therapy Urinary Bladder, Overactive - physiopathology Urological Agents - administration & dosage Urological Agents - chemistry Urological Agents - pharmacokinetics Urological Agents - pharmacology Urological Agents - toxicity
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Zusammenfassung:	Effects of tolterodine hydrogels and tolterodine tablets on the cumulative urinary output in rats. In this study, transdermal gel formulations for tolterodine were developed to investigate the effects of gel matrix and chemical enhancers on drug skin permeation from tolterodine hydrogels. In vitro permeation studies of tolterodine through excised mouse skin were carried out using Franz-type diffusion cells. In the optimum gel formulation, Carbopol 940 was selected as the gel matrix. Compared to gels without enhancer, tolterodine hydrogels with N-methyl pyrrolidone (NMP) showed significant enhancing effect on transdermal permeation of tolterodine (p
ISSN:	0378-5173 1873-3476
DOI:	10.1016/j.ijpharm.2013.07.041