Ozone inhalation in rats: effects on alkaline phosphatase and lactic dehydrogenase isoenzymes in lavage and plasma

Lactic dehydrogenase (LD) isoenzymes were measured to ascertain the tissue giving rise to the increased LD activity in lavage. Also assayed were acid phosphatase, alkaline phosphatase, creatine kinase activities and protein levels. Because previous investigators reported that ozone increased neutrop...

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Veröffentlicht in:	Bull. Environ. Contam. Toxicol.; (United States) 1988-10, Vol.41 (4), p.502-507
Hauptverfasser:	NACHTMAN, J. P, MOON, H. L, MILES, R. C
Format:	Artikel
Sprache:	eng
Schlagworte:	560300 - Chemicals Metabolism & Toxicology ACID PHOSPHATASE Air ALKALINE PHOSPHATASE Alkaline Phosphatase - blood ANIMALS BIOCHEMISTRY Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BLOOD PLASMA BODY FLUIDS CHEMISTRY Environmental pollutants toxicology ENZYMES ERYTHROCYTES ESTERASES HEMATOLOGY HEMIACETAL DEHYDROGENASES HYDROLASES INHALATION INTAKE ISOENZYMES L-Lactate Dehydrogenase - blood LACTATE DEHYDROGENASE LAVAGE Leukocyte Count LEUKOCYTES Male MALES MAMMALS MATERIALS Medical sciences MEDICINE MORPHOLOGY Neutrophils - drug effects Oxidation-Reduction OXIDOREDUCTASES OZONE Ozone - toxicity PHOSPHATASES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS Rats, Inbred F344 RODENTS Therapeutic Irrigation Toxicology VERTEBRATES
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Zusammenfassung:	Lactic dehydrogenase (LD) isoenzymes were measured to ascertain the tissue giving rise to the increased LD activity in lavage. Also assayed were acid phosphatase, alkaline phosphatase, creatine kinase activities and protein levels. Because previous investigators reported that ozone increased neutrophil/lymphocyte ratio, white cell differential and red cell morphology parameters were determined. Lavage protein concentration was found to be the most sensitive to ozone exposure. Lavage analysis provided biochemical indicators of pulmonary disease.
ISSN:	0007-4861 1432-0800
DOI:	10.1007/BF02020993