Intracerebroventricular administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its metabolite 1-methyl-4-phenylpyridinium ion (MPP +) decrease dopamine and increase acetylcholine in the mouse neostriatum

We found that both MPTP and its metabolite MPP + decrease dopamine and increase acetylcholine content of mouse neostriatum when administered intracerebroventricularly (ICV). These observations support the notion that MPP + may be the active neurotoxin formed in brain after MPTP administration. They...

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Veröffentlicht in:	Neuropharmacology 1985-01, Vol.24 (6), p.585-586
Hauptverfasser:	Cavalla, D., Hadjiconstantinou, Maria, Laird, H.E., Neff, N.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Acetylcholine - metabolism Animals Caudate Nucleus - metabolism Choline - metabolism Dopamine - metabolism Injections, Intraventricular Male Mice Putamen - metabolism Pyridines - administration & dosage Pyridines - pharmacology
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