Intracerebroventricular administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its metabolite 1-methyl-4-phenylpyridinium ion (MPP +) decrease dopamine and increase acetylcholine in the mouse neostriatum
We found that both MPTP and its metabolite MPP + decrease dopamine and increase acetylcholine content of mouse neostriatum when administered intracerebroventricularly (ICV). These observations support the notion that MPP + may be the active neurotoxin formed in brain after MPTP administration. They...
Gespeichert in:
Veröffentlicht in: | Neuropharmacology 1985-01, Vol.24 (6), p.585-586 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | We found that both MPTP and its metabolite MPP
+ decrease dopamine and increase acetylcholine content of mouse neostriatum when administered intracerebroventricularly (ICV). These observations support the notion that MPP
+ may be the active neurotoxin formed in brain after MPTP administration. They also suggest that cholinergic mechanisms may be a target of the neurotoxin. |
---|---|
ISSN: | 0028-3908 1873-7064 |
DOI: | 10.1016/0028-3908(85)90069-3 |