Intracerebroventricular administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its metabolite 1-methyl-4-phenylpyridinium ion (MPP +) decrease dopamine and increase acetylcholine in the mouse neostriatum
We found that both MPTP and its metabolite MPP + decrease dopamine and increase acetylcholine content of mouse neostriatum when administered intracerebroventricularly (ICV). These observations support the notion that MPP + may be the active neurotoxin formed in brain after MPTP administration. They...
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| Veröffentlicht in: | Neuropharmacology 1985-01, Vol.24 (6), p.585-586 |
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| container_title | Neuropharmacology |
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| creator | Cavalla, D. Hadjiconstantinou, Maria Laird, H.E. Neff, N.H. |
| description | We found that both MPTP and its metabolite MPP
+ decrease dopamine and increase acetylcholine content of mouse neostriatum when administered intracerebroventricularly (ICV). These observations support the notion that MPP
+ may be the active neurotoxin formed in brain after MPTP administration. They also suggest that cholinergic mechanisms may be a target of the neurotoxin. |
| doi_str_mv | 10.1016/0028-3908(85)90069-3 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0028-3908 |
| ispartof | Neuropharmacology, 1985-01, Vol.24 (6), p.585-586 |
| issn | 0028-3908 1873-7064 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14214397 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Acetylcholine - metabolism Animals Caudate Nucleus - metabolism Choline - metabolism Dopamine - metabolism Injections, Intraventricular Male Mice Putamen - metabolism Pyridines - administration & dosage Pyridines - pharmacology |
| title | Intracerebroventricular administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its metabolite 1-methyl-4-phenylpyridinium ion (MPP +) decrease dopamine and increase acetylcholine in the mouse neostriatum |
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