Acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin to mink

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on adult male mink were assessed. There was a dose-dependent decrease in feed consumption with corresponding body weight loss. Gross necropsy revealed mottling and discoloration of the liver, spleen, and kidneys. Hematologic and thyroid, horm...

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Veröffentlicht in:	Archives of environmental contamination and toxicology 1988-01, Vol.17 (1), p.33-37
Hauptverfasser:	Hochstein, J.R, Aulerich, R.J, Bursian, S.J
Format:	Artikel
Sprache:	eng
Schlagworte:	2,4,5-TRICHLOROPHENOL Animals Biological and medical sciences Body Weight - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Dioxins - toxicity Eating - drug effects FEED INTAKE FONGICIDE FUNGICIDAS FUNGICIDES HERBICIDAS HERBICIDE HERBICIDES INGESTION DE PIENSO Male Medical sciences MICHIGAN Mink - physiology MINKS MORTALIDAD MORTALITE MORTALITY PERDIDA DE PESO PERTE DE POIDS PESO POIDS Polychlorinated Dibenzodioxins - toxicity PRISE ALIMENTAIRE (ANIMAUX) TOXICIDAD TOXICITE TOXICITY Toxicology Various organic compounds VISON WEIGHT WEIGHT LOSSES
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Zusammenfassung:	The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on adult male mink were assessed. There was a dose-dependent decrease in feed consumption with corresponding body weight loss. Gross necropsy revealed mottling and discoloration of the liver, spleen, and kidneys. Hematologic and thyroid, hormone measurements in surviving animals revealed no alterations resulting from TCDD exposure. These results indicate that mink are among the most sensitive species to TCDD and that they can serve as a valuable model to study the impact of environmental dioxins on carnivorous mammalian species.
ISSN:	0090-4341 1432-0703
DOI:	10.1007/BF01055151