Studies on toxic effects of gamma-pentachlorocyclo-hexene (PCCH)

Groups of 15 male rats were fed standard diets containing 350, 3500, or 7000 ppm Gamma-pentachlorocyclo-hexene (PCCH). Body weight gain was significantly decreased after administration of the two highest pcch dosages. All investigated serum parameters were not substantially affected. Neurotoxic effe...

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Veröffentlicht in:	Bulletin of environmental contamination and toxicology 1986-01, Vol.36 (1), p.92-94
Hauptverfasser:	Macholz, R M, Kujawa, M, Lewerenz, H J, Plass, R, Engst, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight - drug effects Eating - drug effects Hexachlorocyclohexane - analogs & derivatives Hexachlorocyclohexane - toxicity Male Nervous System Diseases - chemically induced Organ Size - drug effects Rats Rats, Inbred Strains Time Factors
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Zusammenfassung:	Groups of 15 male rats were fed standard diets containing 350, 3500, or 7000 ppm Gamma-pentachlorocyclo-hexene (PCCH). Body weight gain was significantly decreased after administration of the two highest pcch dosages. All investigated serum parameters were not substantially affected. Neurotoxic effects were shown in all dosage groups. The no toxic dose seems to be considerably below 38 mg/kg body weight.
ISSN:	0007-4861 1432-0800
DOI:	10.1007/BF01623479