Preparation and properties of a mouse monoclonal antibody (W14A) to human chorionic gonadotropin

A mouse monoclonal antibody, W14A, has been prepared which reacts with intact human chorionic gonadotropin and its beta‐subunit, showing less than 2% cross‐reactivity towards the alpha‐subunit and 0.5% cross‐reactivity towards the beta‐subunit of luteinizing hormone. The reagent is suitable for the...

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Veröffentlicht in:	International journal of cancer 1984-04, Vol.33 (4), p.429-434
Hauptverfasser:	Searle, F., Partridge, C. S., Kardana, A., Green, A. J., Buckley, R. G., Begent, R. H. J., Rawlins, G. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Antibodies, Monoclonal - isolation & purification Biological and medical sciences Brain Neoplasms - diagnosis Brain Neoplasms - secondary Choriocarcinoma - diagnosis Choriocarcinoma - metabolism Choriocarcinoma - secondary Chorionic Gonadotropin - analysis Chorionic Gonadotropin - immunology Chorionic Gonadotropin - metabolism Cross Reactions Female Fundamental and applied biological sciences. Psychology Glycoproteins Humans Hybridomas Iodine Radioisotopes Isotope Labeling Mice Mice, Inbred BALB C Neoplasm Transplantation Pregnancy Proteins Radioimmunoassay Rats Tissue Distribution Uterine Neoplasms - diagnosis Uterine Neoplasms - metabolism
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Zusammenfassung:	A mouse monoclonal antibody, W14A, has been prepared which reacts with intact human chorionic gonadotropin and its beta‐subunit, showing less than 2% cross‐reactivity towards the alpha‐subunit and 0.5% cross‐reactivity towards the beta‐subunit of luteinizing hormone. The reagent is suitable for the radioimmunolocalization of choriocarcinoma and trophoblastic teratoma in humans. A preliminary radioimmunoassay has been developed.
ISSN:	0020-7136 1097-0215
DOI:	10.1002/ijc.2910330402