Effect of F super(-) on major salivary glands. The amylase activity, stimulated salivary flow response and cAMP levels in parotid gland of rats consuming F super(-) via drinking water

This study examined the effect of intakes of 25 or 50 ppm fluoride via drinking water for four weeks on the amylase activity of the parotid gland, isoproterenol-stimulated salivary flow and on the amylase activity in saliva fractions. A significant elevation of the tissue amylase activity was seen in the F sub(25) and F sub(50) groups compared to control. The volume of saliva collected for 30 min after isoproterenol injection was higher in the fluoride-treated groups; the amylase activity was also increased. In the glandular tissue cAMP level was augmented. It appears that fluoride may affect the parotid function; it may also influence the salivary amylase activity, presumably by acting on the adenyl cyclase activity.