From the stressed adolescent to the anxious and depressed adult: Investigations in rodent models

Highlights ► Overview of anxiety and depressive disorders in adolescent humans. ► Overview of animal models of anxiety and depression. ► Review lasting effects of social and non-social stressors in adolescent rodents. ► Stress in adolescence increases anxiety-like and depressive behaviour in adultho...

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Veröffentlicht in:	Neuroscience 2013-09, Vol.249, p.242-257
Hauptverfasser:	McCormick, C.M, Green, M.R
Format:	Artikel
Sprache:	eng
Schlagworte:	adolescence Adolescent Adult Age Factors animal model Animals anxiety Anxiety - metabolism Anxiety - psychology Biological and medical sciences Brain - growth & development Brain - metabolism depression Depression - metabolism Depression - psychology Disease Models, Animal Fundamental and applied biological sciences. Psychology glucocorticoids Humans Mice Neurology Rats Rodentia stress Stress, Psychological - metabolism Stress, Psychological - psychology Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► Overview of anxiety and depressive disorders in adolescent humans. ► Overview of animal models of anxiety and depression. ► Review lasting effects of social and non-social stressors in adolescent rodents. ► Stress in adolescence increases anxiety-like and depressive behaviour in adulthood. ► Altered hippocampal development may underlie effects of stressors in adolescence.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.08.063