Bromocriptine Mesylate (Cycloset) for Type 2 Diabetes Mellitus

Cycloset is formulated as a quick-release tablet, and is not interchangeable with other bromocriptine products.1 Drug Dosage Dose form Cost of full course* Bromocriptine mesylate (Cycloset) 0.8 mg once daily in the morning (within two hours of waking); maximal daily dosage: 4.8 mg 0.8-mg tablet $71 to $412, based on daily dosage *-Estimated retail price of one month's treatment based on information obtained at http://www.goodrx.com (accessed February 12, 2013). Potent inhibitors (e.g., macrolide antibiotics, azole antifungals) or inducers (e.g., rifampin, carbamazepine [Tegretol], phenytoin [Dilantin]) of this enzyme may affect serum levels and possibly the action of Cycloset. Because its use with dopamine receptor antagonists (i.e., metoclopramide [Reglan], clozapine [Clozaril], and olanzapine [Zyprexa]) has not been studied, it should not be used concurrently with these agents. Bottom Line Cycloset will lower A1C levels by 0.3 to 0.5 percent when taken alone or in combination with a sulfonylurea, without undesirable adverse effects such as hypoglycemia and weight gain.