Stress and auto-immunity

The etiology of auto-immune disorders is multifactorial. Stress is probably a participating factor. Indeed, a high proportion of patients with auto-immune diseases report uncommon stress before disease onset or disease flare. The biological consequences of stress are increasingly well understood. Gl...

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Veröffentlicht in:	La revue de medecine interne 2013-08, Vol.34 (8), p.487-492
Hauptverfasser:	Delévaux, I, Chamoux, A, Aumaître, O
Format:	Artikel
Sprache:	fre
Schlagworte:	Animals Autoimmune Diseases - etiology Autoimmune Diseases - immunology Autoimmunity - physiology Humans Immune System - physiology Neurosecretory Systems - physiology Stress, Psychological - immunology T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Helper-Inducer - physiology T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - physiology
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Beschreibung
Zusammenfassung:	The etiology of auto-immune disorders is multifactorial. Stress is probably a participating factor. Indeed, a high proportion of patients with auto-immune diseases report uncommon stress before disease onset or disease flare. The biological consequences of stress are increasingly well understood. Glucocorticoids and catecholamines released by hypothalamic-pituitary-adrenal axis during stress will alter the balance Th1/Th2 and the balance Th17/Treg. Stress impairs cellular immunity, decreases immune tolerance and stimulates humoral immunity exposing individuals to autoimmune disease among others. The treatment for autoimmune disease should include stress management.
ISSN:	1768-3122
DOI:	10.1016/j.revmed.2012.10.366