Naloxone exacerbates hypoxic-ischemic brain injury in the neonatal rat

Recent reports suggest that naloxone, an opiate antagonist, may adversely affect the asphyxiated fetus. We found that naloxone exacerbated hypoxic-ischemic brain injury in the 7-day-old rat subjected to unilateral common carotid artery ligation and hypoxia. Moreover, there was no amelioration of sys...

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Veröffentlicht in:	American journal of obstetrics and gynecology 1984-09, Vol.150 (1), p.52-56
Hauptverfasser:	Young, Richard S.K., Hessert, Timothy R., Pritchard, Gary A., Yagel, Susan K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asphyxia Neonatorum - chemically induced Asphyxia Neonatorum - pathology Biological and medical sciences Brain - drug effects Brain - pathology Drug toxicity and drugs side effects treatment Female Humans Infant, Newborn Male Medical sciences Naloxone - adverse effects Pharmacology. Drug treatments Rats Rats, Inbred Strains Sodium Chloride - pharmacology Toxicity: nervous system and muscle
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Zusammenfassung:	Recent reports suggest that naloxone, an opiate antagonist, may adversely affect the asphyxiated fetus. We found that naloxone exacerbated hypoxic-ischemic brain injury in the 7-day-old rat subjected to unilateral common carotid artery ligation and hypoxia. Moreover, there was no amelioration of systemic acidosis or brain edema in naloxone-treated animals compared to animals treated with saline solution. High doses of naloxone may reduce the resistance of the fetus to hypoxic stress.
ISSN:	0002-9378 1097-6868
DOI:	10.1016/S0002-9378(84)80109-X