Antisera to gamma -aminobutyric acid. 2. Immunocytochemical application to the central nervous system

Antisera to gamma -aminobutyric acid. 2. Immunocytochemical application to the central nervous system

An antiserum to gamma -aminobutyric acid (GABA) was tested for the localization of GABAergic neurons in the central nervous system using the unlabeled antibody enzyme method under pre- and postembedding conditions. The antiserum allows the demonstration of immunoreactive GABA in neurons containing o...

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Veröffentlicht in:The journal of histochemistry and cytochemistry 1985-01, Vol.33 (3), p.240-248
Hauptverfasser: Somogyi, P, Hodgson, A J, Chubb, I W, Penke, B, Erdei, A
Format: Artikel
Sprache:eng
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Zusammenfassung:An antiserum to gamma -aminobutyric acid (GABA) was tested for the localization of GABAergic neurons in the central nervous system using the unlabeled antibody enzyme method under pre- and postembedding conditions. The antiserum allows the demonstration of immunoreactive GABA in neurons containing other nueroactive substances; cholecystokinin and GABA immunoreactivities have been shown in the same neurons of the hippocampus. In conclusion, antisera to GABA are good markers for the localization of GABAergic neuronal circuits.
ISSN:0022-1554
DOI:10.1177/33.3.2579123