Effects of early life stress on brain activity: Implications from maternal separation model in rodents

Effects of early life stress on brain activity: Implications from maternal separation model in rodents

Highlights ► MS affects HPA-axis in different manner depending on developmental stage. ► Results of c-Fos study indicate that MS affects the activity of hypothalamic and limbic neurons. ► MS may affect neuronal activity in region- and temporal-specific manners. ► MS deteriorated aversive memory caus...

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Veröffentlicht in:General and comparative endocrinology 2013-01, Vol.181, p.306-309
Hauptverfasser: Nishi, Mayumi, Horii-Hayashi, Noriko, Sasagawa, Takayo, Matsunaga, Wataru
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Animals, Newborn
Brain - metabolism
Brain - physiology
c-Fos
Contextual fear condition
Corticosterone
Corticosterone - metabolism
Endocrinology & Metabolism
Female
Gene expression
HPA-axis
Maternal separation
Mice
Proto-Oncogene Proteins c-fos - metabolism
Stress, Psychological - metabolism
Stress, Psychological - physiopathology
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Zusammenfassung:Highlights ► MS affects HPA-axis in different manner depending on developmental stage. ► Results of c-Fos study indicate that MS affects the activity of hypothalamic and limbic neurons. ► MS may affect neuronal activity in region- and temporal-specific manners. ► MS deteriorated aversive memory caused by contextual fear conditioning. ► MS induced the alteration of gene expression that could be regulated by GR in the hippocampus.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2012.09.024