Angiogenesis in the intermediate lobe of the pituitary gland alters its structure and function

Angiogenesis in the intermediate lobe of the pituitary gland alters its structure and function

Highlights ► Transgenic (Tg) Xenopus expressing VEGF-A in the melanotropes were generated. ► The Tg pars intermedia (PI) was highly vascularized but poorly innervated. ► In the Tg PI, the decrease in the expression of α-MSH and PC2 was noted. ► The Tg frogs placed on a black background displayed inc...

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Veröffentlicht in:General and comparative endocrinology 2013-05, Vol.185, p.10-18
Hauptverfasser: Tanaka, Shigeyasu, Nakakura, Takashi, Jansen, Eric J.R, Unno, Keisuke, Okada, Reiko, Suzuki, Masakazu, Martens, Gerard J.M, Kikuyama, Sakae
Format: Artikel
Sprache:eng
Schlagworte:
Adaptation, Physiological - physiology
alpha-melanocyte-stimulating hormone
alpha-MSH - biosynthesis
alpha-MSH - blood
Angiogenesis
Animals
Animals, Genetically Modified
Anura
Dopamine neuron
Endocrinology & Metabolism
Female
frogs
functional properties
Male
Melanotrope
metamorphosis
Neovascularization, Physiologic
Pituitary gland
Pituitary Gland - blood supply
Pituitary Gland - cytology
Pituitary Gland, Intermediate - blood supply
Pituitary Gland, Intermediate - cytology
Pituitary Gland, Intermediate - physiology
Proprotein Convertase 2 - metabolism
rats
transgenic animals
Transgenic Xenopus
vascular endothelial growth factor A
Vascular Endothelial Growth Factor A - physiology
VEGF-A
Xenopus
Xenopus laevis
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Beschreibung
Zusammenfassung:Highlights ► Transgenic (Tg) Xenopus expressing VEGF-A in the melanotropes were generated. ► The Tg pars intermedia (PI) was highly vascularized but poorly innervated. ► In the Tg PI, the decrease in the expression of α-MSH and PC2 was noted. ► The Tg frogs placed on a black background displayed incomplete color change. ► In the Tg PI, not only morphological but also functional alterations were observed.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2013.01.009