Effect of the neurotoxin MPTP on behavior and cerebral content of neurotransmitters in mice

Effect of the neurotoxin MPTP on behavior and cerebral content of neurotransmitters in mice

We compared the effects of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) on exploratory behavior and conditioning in C57B1 and outbred animals. Two intraperitoneal injections of MPTP suppressed the orienting and exploratory behavior in C57B1 (reductions of both hori...

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Veröffentlicht in:Bulletin of experimental biology and medicine 1999-11, Vol.128 (5), p.1119-1121
Hauptverfasser: Robakidze, T. N., Metkalova, S. E., Miroshnichenko, I. I., Kolgina, N. Yu, Burov, Yu. V.
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container_end_page 1121
container_issue 5
container_start_page 1119
container_title Bulletin of experimental biology and medicine
container_volume 128
creator Robakidze, T. N.
Metkalova, S. E.
Miroshnichenko, I. I.
Kolgina, N. Yu
Burov, Yu. V.
description We compared the effects of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) on exploratory behavior and conditioning in C57B1 and outbred animals. Two intraperitoneal injections of MPTP suppressed the orienting and exploratory behavior in C57B1 (reductions of both horizontal and vertical motor activity), but not in outbred mice, and impaired conditioning. The data indicate the dopaminergic nature of learning disturbances and suggest that the MPTP model may hold a lot of promise for the search for new drugs for the treatment of cognitive disorders in Parkinsonism.[PUBLICATION ABSTRACT]
doi_str_mv 10.1007/BF02433416
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subjects Rodents
title Effect of the neurotoxin MPTP on behavior and cerebral content of neurotransmitters in mice
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