Effect of the neurotoxin MPTP on behavior and cerebral content of neurotransmitters in mice

We compared the effects of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) on exploratory behavior and conditioning in C57B1 and outbred animals. Two intraperitoneal injections of MPTP suppressed the orienting and exploratory behavior in C57B1 (reductions of both hori...

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Veröffentlicht in:Bulletin of experimental biology and medicine 1999-11, Vol.128 (5), p.1119-1121
Hauptverfasser: Robakidze, T. N., Metkalova, S. E., Miroshnichenko, I. I., Kolgina, N. Yu, Burov, Yu. V.
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Sprache:eng
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Zusammenfassung:We compared the effects of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) on exploratory behavior and conditioning in C57B1 and outbred animals. Two intraperitoneal injections of MPTP suppressed the orienting and exploratory behavior in C57B1 (reductions of both horizontal and vertical motor activity), but not in outbred mice, and impaired conditioning. The data indicate the dopaminergic nature of learning disturbances and suggest that the MPTP model may hold a lot of promise for the search for new drugs for the treatment of cognitive disorders in Parkinsonism.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433416