Neuroprotective Effect of Atorvastatin Involves Suppression of TNF-α and Upregulation of IL-10 in a Rat Model of Intracerebral Hemorrhage

We evaluated the neuroprotective effects of atorvastatin (2, 5, and 10 mg/kg) on experimentally induced intracerebral hemorrhage (ICH) in adult rats; controls were administered PBS. Plasma TNF-α and IL-10 levels before and after ICH were analyzed at various time points by enzyme-linked immunosorbent...

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Veröffentlicht in:	Cell biochemistry and biophysics 2013-06, Vol.66 (2), p.337-346
Hauptverfasser:	Ewen, Tu, Qiuting, Liu, Chaogang, Tang, Tao, Tang, Jun, Wu, Liming, Tan, Guanghong, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atorvastatin Calcium Behavior, Animal - drug effects Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Brain Edema - metabolism Brain Edema - pathology Cell Biology Cerebral Hemorrhage - drug therapy Cerebral Hemorrhage - metabolism Cerebral Hemorrhage - pathology Disease Models, Animal Heptanoic Acids - pharmacology Heptanoic Acids - therapeutic use Interleukin-10 - metabolism Life Sciences Male Microglia - pathology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Pharmacology/Toxicology Pyrroles - pharmacology Pyrroles - therapeutic use Rats Rats, Sprague-Dawley Translational Biomedical Research Tumor Necrosis Factor-alpha - metabolism Up-Regulation - drug effects
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Zusammenfassung:	We evaluated the neuroprotective effects of atorvastatin (2, 5, and 10 mg/kg) on experimentally induced intracerebral hemorrhage (ICH) in adult rats; controls were administered PBS. Plasma TNF-α and IL-10 levels before and after ICH were analyzed at various time points by enzyme-linked immunosorbent assay (ELISA) and neurological behavior of rats was assessed by climbing scores. At 3-days postoperatively, brain water contents and TNF-α/IL-10 expression in brain tissue were determined. Histopathological changes and microglial cells in the brain tissue were evaluated by light-microscopy. Post-ICH neurological deficits differed significantly between sham-operated group A and experimental-ICH group B ( P
ISSN:	1085-9195 1559-0283
DOI:	10.1007/s12013-012-9453-z