Baroreflex deficiency hampers angiogenesis after myocardial infarction via acetylcholine-α7-nicotinic ACh receptor in rats

Angiogenesis is critical for re-establishing blood supply to ischaemic myocardium after myocardial infarction (MI). Human studies have associated arterial baroreflex (ABR) deficiency with higher rate of sudden death after MI. The present work was designed to examine whether ABR deficiency affects an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European heart journal 2013-08, Vol.34 (30), p.2412-2420
Hauptverfasser:	Yu, Jian-Guang, Song, Shu-Wei, Shu, He, Fan, Sai-Jun, Liu, Ai-Jun, Liu, Chong, Guo, Wei, Guo, Jin-Min, Miao, Chao-Yu, Su, Ding-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Acetylcholine - physiology alpha7 Nicotinic Acetylcholine Receptor - metabolism alpha7 Nicotinic Acetylcholine Receptor - physiology Angiogenesis Inducing Agents - pharmacology Animals Baroreflex - physiology Blood Pressure - physiology Capillaries - physiology Cholinergic Agonists - pharmacology Cholinesterase Inhibitors - pharmacology Coronary Vessels - physiology Denervation - methods Ketanserin - pharmacology Mice Mice, Knockout Myocardial Infarction - physiopathology Neovascularization, Physiologic - physiology Pyridostigmine Bromide - pharmacology Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Angiogenesis is critical for re-establishing blood supply to ischaemic myocardium after myocardial infarction (MI). Human studies have associated arterial baroreflex (ABR) deficiency with higher rate of sudden death after MI. The present work was designed to examine whether ABR deficiency affects angiogenesis in MI rats. Baroreflex sensitivity (BRS) was determined in conscious rats at 1 month after occlusion of the left anterior descending coronary artery. The survival time was significantly shorter in Sprague-Dawley rats with BRS
ISSN:	1522-9645
DOI:	10.1093/eurheartj/ehr299