A novel stereocontrolled approach to steroid side chain construction: asymmetric synthesis of potential synthon of the vitamin D series

A novel stereocontrolled approach to steroid side chain construction: asymmetric synthesis of potential synthon of the vitamin D series

Stereocontrolled synthesis of (−)-de-AB-8-oxa-cholest-14-en-9-one (2) as an optically active form was achieved starting from the methylene ketone (7). This work constitutes a formal synthesis of de-AB-cholestan (1).

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Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 1984, Vol.25 (41), p.4669-4672
Hauptverfasser: Nemoto, Hideo, Kurobe, Hiroshi, Fukumoto, Keiichiro, Kametani, Tetsuji
Format: Artikel
Sprache:eng
Schlagworte:
Alicyclic compounds, terpenoids, prostaglandins, steroids
Chemistry
Exact sciences and technology
Organic chemistry
Preparations and properties
Steroids
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Zusammenfassung:Stereocontrolled synthesis of (−)-de-AB-8-oxa-cholest-14-en-9-one (2) as an optically active form was achieved starting from the methylene ketone (7). This work constitutes a formal synthesis of de-AB-cholestan (1).
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)91229-8