Cytotoxic Effects Following Micro-irradiation of Cultured Cells Sensitized with Haematoporphyrin Derivative

Cytotoxic Effects Following Micro-irradiation of Cultured Cells Sensitized with Haematoporphyrin Derivative

Haematoporphyrin derivative photosensitization has been studied in single heart cells in tissue culture by laser micro-irradiation ( lambda = 632 multiplied by 8 nm). Changes of beating rate as well as cell death depend on the localization of the microbeam on the various parts of the cell. The resul...

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Veröffentlicht in:International journal of radiation biology 1985-04, Vol.47 (4), p.383-386
Hauptverfasser: Moreno, Giuliana, Salet, Christian
Format: Artikel
Sprache:eng
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Zusammenfassung:Haematoporphyrin derivative photosensitization has been studied in single heart cells in tissue culture by laser micro-irradiation ( lambda = 632 multiplied by 8 nm). Changes of beating rate as well as cell death depend on the localization of the microbeam on the various parts of the cell. The results show that the targets for photodamage are the plasma membrane followed by the mitochondria.
ISSN:0955-3002
DOI:10.1080/713860604