Dexibuprofen for fever in children with upper respiratory tract infection

Background The aim of this study was to investigate the safety and efficacy of dexibuprofen compared to ibuprofen. Methods This double‐blind, double‐dummy study enrolled patients from January 2008 to May 2009 presenting at one of five tertiary care centers in Seoul, Korea with febrile illness who we...

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Veröffentlicht in:	Pediatrics international 2013-08, Vol.55 (4), p.443-449
Hauptverfasser:	Kim, Chang-Keun, Callaway, Zak, Choung, Ji Tae, Yu, Jin Ho, Shim, Kye Shik, Kwon, Eun-Mi, Koh, Young Yull
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Analgesics Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Body Temperature - drug effects Child Child, Preschool Clinical outcomes dexibuprofen Dose-Response Relationship, Drug Double-Blind Method Drug therapy Female Fever Fever - drug therapy Fever - etiology Fever - physiopathology Follow-Up Studies Humans ibuprofen Ibuprofen - administration & dosage Ibuprofen - analogs & derivatives Infant Male Pediatrics randomized controlled trial Respiratory diseases Respiratory Tract Infections - complications Respiratory Tract Infections - drug therapy Retrospective Studies Treatment Outcome upper respiratory tract infection
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Zusammenfassung:	Background The aim of this study was to investigate the safety and efficacy of dexibuprofen compared to ibuprofen. Methods This double‐blind, double‐dummy study enrolled patients from January 2008 to May 2009 presenting at one of five tertiary care centers in Seoul, Korea with febrile illness who were then given one of three active treatments: one dose of dexibuprofen 2.5 or 5 mg/kg (DEX 1); dexibuprofen 3.5 or 7 mg/kg (DEX 2); or ibuprofen 5 or 10 mg/kg (control) syrup. Those with a temperature
ISSN:	1328-8067 1442-200X
DOI:	10.1111/ped.12125