Lymph Node Harvest in Esophageal Cancer After Neoadjuvant Chemoradiotherapy

Background This study was designed to determine the effects of lymph node (LN) harvest on survival in esophageal cancer after neoadjuvant chemoradiation (nCRT). Methods An analysis of surgically resected esophageal cancer patients after nCRT was performed to determine an association between the numb...

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Veröffentlicht in:	Annals of surgical oncology 2013-09, Vol.20 (9), p.3038-3043
Hauptverfasser:	Shridhar, Ravi, Hoffe, Sarah E., Almhanna, Khaldoun, Weber, Jill M., Chuong, Michael D., Karl, Richard C., Meredith, Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - therapy Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Chemoradiotherapy - mortality Cisplatin - administration & dosage Combined Modality Therapy Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Esophagectomy Female Fluorouracil - administration & dosage Follow-Up Studies Humans Lymph Node Excision - mortality Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Neoadjuvant Therapy - mortality Neoplasm Staging Oncology Organoplatinum Compounds - administration & dosage Paclitaxel - administration & dosage Prognosis Surgery Surgical Oncology Survival Rate Thoracic Oncology
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Zusammenfassung:	Background This study was designed to determine the effects of lymph node (LN) harvest on survival in esophageal cancer after neoadjuvant chemoradiation (nCRT). Methods An analysis of surgically resected esophageal cancer patients after nCRT was performed to determine an association between the number of LNs resected and survival. Overall survival (OS) and disease-free survival (DFS) curves were calculated according to the Kaplan–Meier method and log-rank analysis. Multivariate analysis (MVA) was performed by the Cox proportional hazard model. Results We identified 358 patients with a mean follow-up of 27.3 months. The number of LN removed was not impacted by the type of surgical procedure. The number of LNs removed (
ISSN:	1068-9265 1534-4681
DOI:	10.1245/s10434-013-2988-4