Presynaptic serotonin receptors regulate the release of super(3)H-serotonin in hypothalamic slices of the rabbit

Presynaptic serotonin receptors regulate the release of super(3)H-serotonin in hypothalamic slices of the rabbit

Hypothalamic slices of the rabbit brain were incubated with super(3)H-serotonin ( super(3)H-5HT). After the incubation and an initial washout period, a nearly constant basal efflux of tritium was detected. The experiments suggest that in rabbit hypothalamic slices, the release of super(3)H-5HT is co...

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Veröffentlicht in:Naunyn-Schmiedeberg's archives of pharmacology 1984-01, Vol.327 (2), p.102-106
Hauptverfasser: Verbeuren, T J, Coen, E P, Schoups, A, van de Velde, R, Baeyens, R, Potter, W P
Format: Artikel
Sprache:eng
Schlagworte:
hypothalamus
rabbits
serotonin
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Zusammenfassung:Hypothalamic slices of the rabbit brain were incubated with super(3)H-serotonin ( super(3)H-5HT). After the incubation and an initial washout period, a nearly constant basal efflux of tritium was detected. The experiments suggest that in rabbit hypothalamic slices, the release of super(3)H-5HT is controlled by a negative feedback mechanism acting via presynaptic serotonin receptors.
ISSN:0028-1298