Involvement of miRNAs in equine follicle development

Involvement of miRNAs in equine follicle development

Previous evidence from in vitro studies suggests specific roles for a subset of miRNAs, including miR-21, miR-23a, miR-145, miR-503, miR-224, miR-383, miR-378, miR-132, and miR-212, in regulating ovarian follicle development. The objective of this study was to determine changes in the levels of thes...

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Veröffentlicht in:Reproduction (Cambridge, England) England), 2013-09, Vol.146 (3), p.273-282
Hauptverfasser: Schauer, S N, Sontakke, S D, Watson, E D, Esteves, C L, Donadeu, F X
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chorionic Gonadotropin - physiology
Dinoprostone - metabolism
Female
Follicular Fluid - physiology
Horses - physiology
Insulin-Like Growth Factor I - physiology
MicroRNAs - physiology
Ovarian Follicle - metabolism
Random Allocation
Steroids - physiology
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Zusammenfassung:Previous evidence from in vitro studies suggests specific roles for a subset of miRNAs, including miR-21, miR-23a, miR-145, miR-503, miR-224, miR-383, miR-378, miR-132, and miR-212, in regulating ovarian follicle development. The objective of this study was to determine changes in the levels of these miRNAs in relation to follicle selection, maturation, and ovulation in the monovular equine ovary. In Experiment 1, follicular fluid was aspirated during ovulatory cycles from the dominant (DO) and largest subordinate (S) follicles of an ovulatory wave and the dominant (DA) follicle of a mid-cycle anovulatory wave (n=6 mares). Follicular fluid levels of progesterone and estradiol were lower (P
ISSN:1470-1626
1741-7899
DOI:10.1530/REP-13-0107