Function and Autoregulation of Yeast Copperthionein

The CUP1 gene of yeast encodes a small, metallothionein-like protein that binds to and is inducible by copper. A gene replacement experiment shows that this protein protects cells against copper poisoning but is dispensable for normal cellular growth and development throughout the yeast life cycle....

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1985-05, Vol.228 (4700), p.685-690
Hauptverfasser:	Hamer, Dean H., Thiele, Dennis J., Lemontt, Jeffrey E.
Format:	Artikel
Sprache:	eng
Schlagworte:	560302 - Chemicals Metabolism & Toxicology- Microorganisms- (-1987) Autoregulation BIOLOGICAL ADAPTATION Biological and medical sciences Biological research BIOLOGICAL VARIABILITY Biology of microorganisms of confirmed or potential industrial interest Biology, Experimental Biotechnology Carrier Proteins Cell physiology COPPER Copper - metabolism Copper Sulfate Diploidy DNA ELEMENTS Enzyme Induction Fundamental and applied biological sciences. Psychology FUNGI Genes Genes, Fungal Genetic loci GENETIC VARIABILITY Genetics Heavy metals HOMEOSTASIS Messenger RNA METALLOPROTEINS METALLOTHIONEIN Metallothionein - biosynthesis Metallothionein - genetics Metallothionein - physiology METALS MICROORGANISMS Miscellaneous Mission oriented research Molecular and cellular biology Mutation Observations Operon ORGANIC COMPOUNDS PLANTS Plasmids Polypeptides PROTEINS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RNA, Messenger - biosynthesis Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics SYNTHESIS TOXICITY TRANSITION ELEMENTS YEASTS
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Beschreibung
Zusammenfassung:	The CUP1 gene of yeast encodes a small, metallothionein-like protein that binds to and is inducible by copper. A gene replacement experiment shows that this protein protects cells against copper poisoning but is dispensable for normal cellular growth and development throughout the yeast life cycle. The transcription of CUP1 is negatively autoregulated. This feedback mechanism, which is mediated through upstream control sequences, may play an important role in heavy metal homeostasis.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.3887570