Effect of preweaning undernutrition on cadmium-induced metallothionein levels in liver and cadmium distribution in different tissues

The purpose of this investigation was to observe the effect of preweaning undernutrition on cadmium-induced metallothionein levels in liver and cadmium distribution in different tissues. Preweaning undernutrition was produced by increasing the litter size. At 21 days of age, both control and underno...

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Veröffentlicht in:	Environ. Res.; (United States) 1982-10, Vol.29 (1), p.190-195
Hauptverfasser:	Asokan, P., Murti, C.R.Krishna
Format:	Artikel
Sprache:	eng
Schlagworte:	560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) Animal Population Groups - metabolism ANIMALS Animals, Suckling - metabolism BIOLOGICAL EFFECTS BIOSYNTHESIS BODY CADMIUM Cadmium - adverse effects Cadmium - metabolism DIGESTIVE SYSTEM DISTRIBUTION ELEMENTS GLANDS INJECTION INTAKE Intestinal Mucosa - metabolism INTRAPERITONEAL INJECTION Kidney - metabolism LIVER Liver - metabolism MAMMALS METALLOPROTEINS Metalloproteins - metabolism METALLOTHIONEIN Metallothionein - metabolism METALS Myocardium - metabolism Nutrition Disorders - metabolism NUTRITIONAL DEFICIENCY ORGANIC COMPOUNDS ORGANS PROTEINS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS RODENTS Spleen - metabolism SYNTHESIS TISSUE DISTRIBUTION VERTEBRATES
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Zusammenfassung:	The purpose of this investigation was to observe the effect of preweaning undernutrition on cadmium-induced metallothionein levels in liver and cadmium distribution in different tissues. Preweaning undernutrition was produced by increasing the litter size. At 21 days of age, both control and undernourished rats received a single intraperitoneal injection of cadmium (0.75 mg Cd 2+/kg as CdCl 2H 2O). Animals were killed and metallothionein levels in liver and cadmium content in different tissues were estimated. Preweaning undernutrition resulted in a significant increase in native metallothionein levels in the liver. Cadmium administration induced metallothionein only in well-nourished rats. Cadmium distribution in different tissues was also significantly altered by preweaning undernutrition.
ISSN:	0013-9351 1096-0953
DOI:	10.1016/0013-9351(82)90019-6