Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. studies with paf-receptor antagonist kadsurenone

Evidence from three types of experiments indicates that platelet activating factor (PAF) is an important mediator of endotoxin-induced hypotension in rats. a) Endotoxin infusion stimulates the time-dependent appearance of PAF in the blood. b) PAF infusion results immediately (

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Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 1985-03, Vol.127 (3), p.799-808
Hauptverfasser:	Doebber, Thomas W., Wu, Margaret S., Robbins, James C., Choy, Betty Ma, Chang, Michael N., Shen, T.Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Benzofurans Benzopyrans - pharmacology Endotoxins Escherichia coli Exact sciences and technology Female Hypotension - chemically induced Kinetics Lignans Other techniques and industries Platelet Activating Factor - physiology Platelet Membrane Glycoproteins Rats Rats, Inbred Strains Receptors, Cell Surface - drug effects Receptors, Cell Surface - physiology Receptors, G-Protein-Coupled
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Beschreibung
Zusammenfassung:	Evidence from three types of experiments indicates that platelet activating factor (PAF) is an important mediator of endotoxin-induced hypotension in rats. a) Endotoxin infusion stimulates the time-dependent appearance of PAF in the blood. b) PAF infusion results immediately (
ISSN:	0006-291X 1090-2104
DOI:	10.1016/S0006-291X(85)80014-0