Functionalized liposome purification via Liposome Extruder Purification (LEP)

Liposome Extruder Purification (LEP) allows for the rapid purification of diverse liposome formulations using the same extrusion apparatus employed during liposome formation. The LEP process provides a means for purifying functionalized liposomes from non-conjugated drug or protein contaminants with...

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Veröffentlicht in:	Analyst (London) 2013-09, Vol.138 (17), p.4746-4751
Hauptverfasser:	Alves, Nathan J, Cusick, William, Stefanick, Jared F, Ashley, Jonathan D, Handlogten, Michael W, Bilgicer, Basar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Chemical Fractionation - methods Chemistry, Pharmaceutical Liposomes - chemistry Liposomes - isolation & purification Time Factors
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Liposome Extruder Purification (LEP) allows for the rapid purification of diverse liposome formulations using the same extrusion apparatus employed during liposome formation. The LEP process provides a means for purifying functionalized liposomes from non-conjugated drug or protein contaminants with >93% liposome recovery and >93% contaminant removal in a single step.
ISSN:	0003-2654 1364-5528
DOI:	10.1039/c3an00680h