Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine

A key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na-Ph3P with aldehydes was synthesized and characterized, which confirmed the reaction mechanism. The decarboxylation of this stable intermediate was a convenient approach for Wittig difluroolefination. Its react...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (68), p.7513-7515
Hauptverfasser: Zheng, Jian, Cai, Ji, Lin, Jin-Hong, Guo, Yong, Xiao, Ji-Chang
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Sprache:eng
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Zusammenfassung:A key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na-Ph3P with aldehydes was synthesized and characterized, which confirmed the reaction mechanism. The decarboxylation of this stable intermediate was a convenient approach for Wittig difluroolefination. Its reactivity could be adjusted by the modification of the substituent on the phosphorus.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc44271c