Quantifying mRNA coding growth genes in the maternal circulation to detect fetal growth restriction

Objective To examine whether mRNA circulating in maternal blood coding genes regulating fetal growth are differentially expressed in (1) severe preterm fetal growth restriction (FGR) and (2) at 28 weeks' gestation in pregnancies destined to develop FGR at term. Study Design mRNA coding growth g...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2013-08, Vol.209 (2), p.133.e1-133.e9
Hauptverfasser:	Whitehead, Clare L., MBChB, Walker, Susan P., MD, Mendis, Sonali, BMedSci, Lappas, Martha, PhD, Tong, Stephen, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - genetics ADAM12 Protein Adult biomarker Female Fetal Development fetal growth restriction Fetal Growth Retardation - diagnosis free RNA Humans Insulin-Like Growth Factor Binding Proteins - genetics maternal circulation Membrane Proteins - genetics Obstetrics and Gynecology placenta Pregnancy - blood Receptors, Somatomedin - genetics RNA, Messenger - blood Somatomedins - genetics
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Beschreibung
Zusammenfassung:	Objective To examine whether mRNA circulating in maternal blood coding genes regulating fetal growth are differentially expressed in (1) severe preterm fetal growth restriction (FGR) and (2) at 28 weeks' gestation in pregnancies destined to develop FGR at term. Study Design mRNA coding growth genes were measured in 2 independent cohorts. The first was women diagnosed with severe preterm FGR (
ISSN:	0002-9378 1097-6868
DOI:	10.1016/j.ajog.2013.04.011