Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA
We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discriminatio...
Gespeichert in:
| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2013-08, Vol.49 (67), p.7397-7399 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7399 |
|---|---|
| container_issue | 67 |
| container_start_page | 7397 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 49 |
| creator | Blechinger, Jenny Pieper, Hanna Marzenell, Paul Kovbasyuk, Larisa Serva, Andrius Starkuviene, Vytaute Erfle, Holger Mokhir, Andriy |
| description | We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers. |
| doi_str_mv | 10.1039/c3cc43174f |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1413164953</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1413164953</sourcerecordid><originalsourceid>FETCH-LOGICAL-c287t-976641c11b81b9854d9a23569d3a4581d5db05e082ed44cca507e4017692359e3</originalsourceid><addsrcrecordid>eNpFkMtKAzEUhoMotlY3PoBkp4ijOZPLJDtL8QbVghdwN2SSDI3MNDWZLvr2TmnVszkH_o-fw4fQKZBrIFTdGGoMo1Cweg8NgQqWcSY_9zc3V1lBGR-go5S-SD_A5SEa5FQKqhQfotu3eYjdFe5cbP1CN80at8H62juL8_Ns9uzw68s4YZ2wX8x95bsQEw41br2JoY-O0UGtm-ROdnuEPu7v3ieP2XT28DQZTzOTy6LLVCEEAwNQSaiU5MwqnVMulKWacQmW24pwR2TuLGPGaE4KxwgUQvWYcnSELra9yxi-Vy51ZeuTcU2jFy6sUgkMKAimOO3Ryy3af5hSdHW5jL7VcV0CKTfGyn9jPXy2611VrbN_6K8i-gNGGGOK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1413164953</pqid></control><display><type>article</type><title>Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Blechinger, Jenny ; Pieper, Hanna ; Marzenell, Paul ; Kovbasyuk, Larisa ; Serva, Andrius ; Starkuviene, Vytaute ; Erfle, Holger ; Mokhir, Andriy</creator><creatorcontrib>Blechinger, Jenny ; Pieper, Hanna ; Marzenell, Paul ; Kovbasyuk, Larisa ; Serva, Andrius ; Starkuviene, Vytaute ; Erfle, Holger ; Mokhir, Andriy</creatorcontrib><description>We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c3cc43174f</identifier><identifier>PMID: 23863995</identifier><language>eng</language><publisher>England</publisher><subject>Base Sequence ; Down-Regulation - drug effects ; HeLa Cells ; Humans ; MicroRNAs - antagonists & inhibitors ; MicroRNAs - chemistry ; Oligonucleotides - chemistry ; Oligonucleotides - pharmacology ; Stilbenes - chemistry ; Stilbenes - pharmacology</subject><ispartof>Chemical communications (Cambridge, England), 2013-08, Vol.49 (67), p.7397-7399</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c287t-976641c11b81b9854d9a23569d3a4581d5db05e082ed44cca507e4017692359e3</citedby><cites>FETCH-LOGICAL-c287t-976641c11b81b9854d9a23569d3a4581d5db05e082ed44cca507e4017692359e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23863995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blechinger, Jenny</creatorcontrib><creatorcontrib>Pieper, Hanna</creatorcontrib><creatorcontrib>Marzenell, Paul</creatorcontrib><creatorcontrib>Kovbasyuk, Larisa</creatorcontrib><creatorcontrib>Serva, Andrius</creatorcontrib><creatorcontrib>Starkuviene, Vytaute</creatorcontrib><creatorcontrib>Erfle, Holger</creatorcontrib><creatorcontrib>Mokhir, Andriy</creatorcontrib><title>Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.</description><subject>Base Sequence</subject><subject>Down-Regulation - drug effects</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>MicroRNAs - antagonists & inhibitors</subject><subject>MicroRNAs - chemistry</subject><subject>Oligonucleotides - chemistry</subject><subject>Oligonucleotides - pharmacology</subject><subject>Stilbenes - chemistry</subject><subject>Stilbenes - pharmacology</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtKAzEUhoMotlY3PoBkp4ijOZPLJDtL8QbVghdwN2SSDI3MNDWZLvr2TmnVszkH_o-fw4fQKZBrIFTdGGoMo1Cweg8NgQqWcSY_9zc3V1lBGR-go5S-SD_A5SEa5FQKqhQfotu3eYjdFe5cbP1CN80at8H62juL8_Ns9uzw68s4YZ2wX8x95bsQEw41br2JoY-O0UGtm-ROdnuEPu7v3ieP2XT28DQZTzOTy6LLVCEEAwNQSaiU5MwqnVMulKWacQmW24pwR2TuLGPGaE4KxwgUQvWYcnSELra9yxi-Vy51ZeuTcU2jFy6sUgkMKAimOO3Ryy3af5hSdHW5jL7VcV0CKTfGyn9jPXy2611VrbN_6K8i-gNGGGOK</recordid><startdate>20130828</startdate><enddate>20130828</enddate><creator>Blechinger, Jenny</creator><creator>Pieper, Hanna</creator><creator>Marzenell, Paul</creator><creator>Kovbasyuk, Larisa</creator><creator>Serva, Andrius</creator><creator>Starkuviene, Vytaute</creator><creator>Erfle, Holger</creator><creator>Mokhir, Andriy</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130828</creationdate><title>Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA</title><author>Blechinger, Jenny ; Pieper, Hanna ; Marzenell, Paul ; Kovbasyuk, Larisa ; Serva, Andrius ; Starkuviene, Vytaute ; Erfle, Holger ; Mokhir, Andriy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-976641c11b81b9854d9a23569d3a4581d5db05e082ed44cca507e4017692359e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Base Sequence</topic><topic>Down-Regulation - drug effects</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>MicroRNAs - antagonists & inhibitors</topic><topic>MicroRNAs - chemistry</topic><topic>Oligonucleotides - chemistry</topic><topic>Oligonucleotides - pharmacology</topic><topic>Stilbenes - chemistry</topic><topic>Stilbenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blechinger, Jenny</creatorcontrib><creatorcontrib>Pieper, Hanna</creatorcontrib><creatorcontrib>Marzenell, Paul</creatorcontrib><creatorcontrib>Kovbasyuk, Larisa</creatorcontrib><creatorcontrib>Serva, Andrius</creatorcontrib><creatorcontrib>Starkuviene, Vytaute</creatorcontrib><creatorcontrib>Erfle, Holger</creatorcontrib><creatorcontrib>Mokhir, Andriy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blechinger, Jenny</au><au>Pieper, Hanna</au><au>Marzenell, Paul</au><au>Kovbasyuk, Larisa</au><au>Serva, Andrius</au><au>Starkuviene, Vytaute</au><au>Erfle, Holger</au><au>Mokhir, Andriy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2013-08-28</date><risdate>2013</risdate><volume>49</volume><issue>67</issue><spage>7397</spage><epage>7399</epage><pages>7397-7399</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.</abstract><cop>England</cop><pmid>23863995</pmid><doi>10.1039/c3cc43174f</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2013-08, Vol.49 (67), p.7397-7399 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1413164953 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Base Sequence Down-Regulation - drug effects HeLa Cells Humans MicroRNAs - antagonists & inhibitors MicroRNAs - chemistry Oligonucleotides - chemistry Oligonucleotides - pharmacology Stilbenes - chemistry Stilbenes - pharmacology |
| title | Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T23%3A24%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Short,%20terminally%20modified%202'-OMe%20RNAs%20as%20inhibitors%20of%20microRNA&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Blechinger,%20Jenny&rft.date=2013-08-28&rft.volume=49&rft.issue=67&rft.spage=7397&rft.epage=7399&rft.pages=7397-7399&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/c3cc43174f&rft_dat=%3Cproquest_cross%3E1413164953%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1413164953&rft_id=info:pmid/23863995&rfr_iscdi=true |