Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA

Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA

We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discriminatio...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-08, Vol.49 (67), p.7397-7399
Hauptverfasser: Blechinger, Jenny, Pieper, Hanna, Marzenell, Paul, Kovbasyuk, Larisa, Serva, Andrius, Starkuviene, Vytaute, Erfle, Holger, Mokhir, Andriy
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
Down-Regulation - drug effects
HeLa Cells
Humans
MicroRNAs - antagonists & inhibitors
MicroRNAs - chemistry
Oligonucleotides - chemistry
Oligonucleotides - pharmacology
Stilbenes - chemistry
Stilbenes - pharmacology
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Zusammenfassung:We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc43174f