Long-Term Neurodevelopmental Outcome with Hypoxic-Ischemic Encephalopathy

Objectives To determine the long-term neurodevelopmental outcome for children after hypoxic-ischemic encephalopathy (HIE) without major disability, and to examine neonatal injury patterns detected on cerebral magnetic resonance imaging (MRI) in relation to later deficits. Study design Prospectively enrolled children with HIE and neonatal cerebral MRI data (n = 68) were examined at a mean age of 11.2 years (range, 8.2-15.7 years). Eleven children had a major disability (ie, cerebral palsy or mental retardation). Brain injury was scored according to the region and extent of injury. Results Children without major disability (n = 57) had lower full-scale and performance IQ scores compared with norms ( P = .02 and .01, respectively), and the proportion of children with an IQ