Two types of omega -agatoxin IVA-sensitive Ca super(2+ )channels are coupled to adrenaline and noradrenaline release in bovine adrenal chromaffin cells

Two types of omega -agatoxin IVA-sensitive Ca super(2+ )channels are coupled to adrenaline and noradrenaline release in bovine adrenal chromaffin cells

To clarify the role of P-type Ca super(2+ )channels in catecholamine release from adrenal chromaffin cells we examined the concentration dependence of the effect of omega -agatoxin IVA on the release both of adrenaline and noradrenaline induced by a K super(+)-evoked depolarization. omega -Agatoxin...

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Veröffentlicht in:Pflügers Archiv 1997-08, Vol.434 (5), p.592-598
Hauptverfasser: Baltazar, Graca, Ladeira, Idalina, Carvalho, Arselio P, Duarte, Emilia P
Format: Artikel
Sprache:eng
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Zusammenfassung:To clarify the role of P-type Ca super(2+ )channels in catecholamine release from adrenal chromaffin cells we examined the concentration dependence of the effect of omega -agatoxin IVA on the release both of adrenaline and noradrenaline induced by a K super(+)-evoked depolarization. omega -Agatoxin IVA caused a biphasic dose-dependent inhibition of secretion with a high-potency component (IC sub(50)
ISSN:0031-6768
1432-2013
DOI:10.1007/s004240050441