ANTIBACTERIAL AND IMMUNOMODULATING PROPERTIES OF LACTO- AND BIFIDOBACTERIA STRAINS AT EXPERIMENTAL STAPHYLOCOCCAL INFECTION

Antibacterial and immunomodulating properties of Lactobacillus delbrueckii subsp. bulgaricus IMV B-7281, Lactobacillus casei IMV B-7280, Lactobacillus acidophilus B-7279 IMV, Bifidobacterium longum VK1 and Bifidobacterium bifidum VK2 strains were determined at the experimental model of staphylococcal infection of mice. It was established that under the influence of these strains it was significantly reduced the number of Staphylococcus aureus colonies, which were seeded out from kidneys of infected mice. At the same time after introduction by mice with staphylococcal infection of separate probiotic strains of lacto- and bifidobacteria it was observed increasing of the CD^sub 4^/CD^sub 8^ immunoregulatory index, and also the number of ...-and ...-cells in spleen. Lactobacillus delbrueckii subsp bulgaricus IMV B-7281, Lactobacillus casei IMV B-7280, Lactobacillus acidophilus B-7279 IMV, Bifidobac terium bifidum VK2 and Bifidobacterium longum VK1 strains found to be perspective for probiotics creation, that could be effective against staphylococcal infection and for the immunity correction. (ProQuest: ... denotes formulae/symbols omitted.)