Morphologic Evaluation of P53 Apoptotic Signaling Responses and Proliferative Activity of Ki-67 in Oral Lichen Planus, Oral Squamous Cell Carcinoma and Normal Specimens
Oral lichen planus is not a rare condition in human being. This inflammatory disease is generally regarded as a benign pathology; however, transformation toward malignant conditions in some cases has forced many physicians to consider lichen planus as a premalignant entity. This study investigates a...
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Veröffentlicht in: | Journal of medical sciences (Faisalābād, Pakistan) Pakistan), 2012-02, Vol.12 (2), p.51-56 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Oral lichen planus is not a rare condition in human being. This inflammatory disease is generally regarded as a benign pathology; however, transformation toward malignant conditions in some cases has forced many physicians to consider lichen planus as a premalignant entity. This study investigates and compares the rate of Ki-67 and P53 expression in patients with oral lichen planus and oral Squamous Cell Carcinoma (SCC) in comparison with normal subjects. In this prospective study, paraffin-embedded specimens of histopathologically proved oral lichen planus (n = 30), oral SCC (n = 20) and oral buccal mucosa of normal subjects (n = 20) were examined at Tabriz Imam Reza Hospital within a one-year period of time. Monoclonal antibodies against Ki-67 and P53 were used for determining the rate of expression of these two markers. The three groups were matched for patients' age and gender. Ki-67 was expressed in 26 patients (86.7%) in lichen planus group, in 20 patients (100%) in SCC group and in 4 normal subjects (20%). The rate of Ki-67 positivity was significantly higher in lichen planus and SCC groups than in normal subjects (p |
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ISSN: | 1682-4474 1812-5727 |
DOI: | 10.3923/jms.2012.51.56 |