Activation of receptor for advanced glycation end products contributes to aortic remodeling and endothelial dysfunction in sinoaortic denervated rats

Abstract Objective The aim of present study was to test the hypothesis that activation of receptor for advanced glycation end products (RAGE) pathway contributes to aortic remodeling and endothelial dysfunction in sinoaortic denervated (SAD) rats. Methods and results Experiment 1 : 8 weeks after sin...

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Veröffentlicht in:	Atherosclerosis 2013-08, Vol.229 (2), p.287-294
Hauptverfasser:	Wu, Feng, Feng, Jin-Zhong, Qiu, Yi-Hua, Yu, Feng-Bin, Zhang, Jian-Zhong, Zhou, Wei, Yu, Feng, Wang, Guo-Kun, An, Li-Na, Ni, Fei-Hua, Wu, Hong, Zhao, Xian-Xian, Qin, Yong-Wen, Luo, He-De
Format:	Artikel
Sprache:	eng
Schlagworte:	advanced glycation end products aldehyde reductase Aldehyde Reductase - metabolism Animals Aorta - innervation Aorta - metabolism Aorta - physiopathology Aortic remodeling arginine atherosclerosis Autonomic Denervation Baroreflex - physiology bioavailability Cardiovascular Cardiovascular Diseases - metabolism Cardiovascular Diseases - physiopathology collagen Disease Models, Animal Endothelial dysfunction endothelial nitric oxide synthase Endothelium, Vascular - innervation Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Inflammation Lactoylglutathione Lyase - metabolism Male malondialdehyde Mitochondria - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Oxidative stress Oxidative Stress - physiology Rats Rats, Sprague-Dawley reactive oxygen species Receptor for Advanced Glycation End Products Receptors, Immunologic - metabolism Sinoaortic denervation Vasculitis - metabolism Vasculitis - physiopathology
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