Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate

Chemical synthesis and characterization of a lipophilic ester conjugate, propofol stearate and evaluation of its anticancer efficacy on human breast cancer cell lines MDA-MB-361, MCF-7 and MDA-MB-231. The chemical structure of the synthesized conjugate was characterized by spectroscopic studies. Its...

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Veröffentlicht in:	Anticancer research 2013-06, Vol.33 (6), p.2517-2524
Hauptverfasser:	Khan, Azmat Ali, Alanazi, Amer M, Jabeen, Mumtaz, Chauhan, Arun, Abdelhameed, Ali Sabir
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Breast Neoplasms - drug therapy Cell Adhesion - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Drug Design Esters - chemistry Female Humans Propofol - analogs & derivatives Propofol - chemical synthesis Propofol - chemistry Propofol - pharmacology Stearates - chemical synthesis Stearates - chemistry Stearates - pharmacology Stearic Acids - chemistry
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