Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate

Chemical synthesis and characterization of a lipophilic ester conjugate, propofol stearate and evaluation of its anticancer efficacy on human breast cancer cell lines MDA-MB-361, MCF-7 and MDA-MB-231. The chemical structure of the synthesized conjugate was characterized by spectroscopic studies. Its...

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Veröffentlicht in:	Anticancer research 2013-06, Vol.33 (6), p.2517-2524
Hauptverfasser:	Khan, Azmat Ali, Alanazi, Amer M, Jabeen, Mumtaz, Chauhan, Arun, Abdelhameed, Ali Sabir
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Breast Neoplasms - drug therapy Cell Adhesion - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Drug Design Esters - chemistry Female Humans Propofol - analogs & derivatives Propofol - chemical synthesis Propofol - chemistry Propofol - pharmacology Stearates - chemical synthesis Stearates - chemistry Stearates - pharmacology Stearic Acids - chemistry
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Zusammenfassung:	Chemical synthesis and characterization of a lipophilic ester conjugate, propofol stearate and evaluation of its anticancer efficacy on human breast cancer cell lines MDA-MB-361, MCF-7 and MDA-MB-231. The chemical structure of the synthesized conjugate was characterized by spectroscopic studies. Its anticancer potential was evaluated on the basis of growth inhibition, cancer cell adhesion and migration and apoptosis induction. Propofol stearate exhibited significant (p
ISSN:	0250-7005 1791-7530